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Seeing Zebras

Anthony Rudine -- Well, it's a new year and a new semester. I just can't wait. I am extremely excited that this will be my last semester of actual classroom instruction, then I am on to my clinical years of treating and healing.

As is usual over the Christmas break, I had a round of checkups from my own physicians to make sure I was still hanging in there, and as usual, everything checked out fine.

Unfortunately, my family physician diagnosed me with a new disease this year – medicalstudentitis. I informed him that by learning about new diseases in medical school and learning of their symptoms, many of my friends and I had begun to diagnose ourselves with everything imaginable. He gave a quick chuckle and told me not to worry – what a great guy.

Medical school is an interesting beast. I'm sure you all have heard of the saying – 'when you hear hoofbeats, think horses, not zebras.' This is meant to say that the most obvious cause and the most simple explanation are usually correct. It is exceedingly unlikely that we, as medical students, will even encounter some of the rare diseases discussed during morning lecture.

My issue is this. How am I not to think I have a rare disease when the teaching is focused more on recognizing symptoms, of which many conditions share, and less on the statistical representation of the disease in society? How am I to separate the rare from the common, when much of my learning focuses on the rarities?

Let me elaborate. I live in Lubbock, Texas, a dry and windy place at any time of the year. A couple of months ago I started to itch. My first thought? Liver failure. Not dry skin from the dry and windy climate, but full blown liver failure. By the end of the day I figured I had hepatitis and was quite close to checking myself in to the hospital for further evaluation. Thank goodness I did not.

When I explained this to my family physician, he acted like he had seen the symptoms before -- medical students coming in (he is a professor at a medical school as well) to his office and describing to him why they had some rare disease because they had recently developed symptoms. He had seen it many times. Medicalstudentitis. And I had a severe case.

Another example. A good friend of mine in medical school showed up to class with a headache one fine morning. Unbeknownst to me, he had already diagnosed himself as well, and was seriously considering requesting an MRI of his head. His diagnosis? Brain tumor.

Here is the point. When am I to recognize that the rare diseases and conditions are actually rare? When can I distinguish the simple headache from the brain tumor? Certainly not now.

It is not, in my opinion, a question of knowledge – some symptoms are simply the same for many different conditions – it is a question of judgment. One must see so many presentations of the same problems to begin to notice abnormalities in the common versus the rare.

What took me some time to realize is that everyone has symptoms of many diseases. Additionally, I forget that I'm learning about the worst diseases possible while in school, and much more time is spent on the abnormal than the common and normal variations. So, it is only logical for me to conclude, based on that knowledge, that it is the worst case scenario – it is the only thing I know.

I'm just curious when this will change.

January 9, 2006 | Permalink

Comments

i had a good laugh on this one.. and obviously its the problem with diagnosis.. call it diagnostitis? :D

Posted by: keith | Jan 9, 2006 10:06:19 AM

Anthony, this is very funny! I'm a psych grad student, and we all have the same problem with self-diagnosis, and wondering about friends and family :)

Posted by: Donna | Jan 9, 2006 11:12:07 AM

When we went through the psychology part of neuro, the diagnosing game became really funny! Every classmate, family member, and even a few of our professors was 'diagnoised' with a personality disorder, or depression, or mania...
Hopefully though, doctors won't misdiagnoise a real problem for medicalstudentitis.

Posted by: Jaime | Jan 9, 2006 11:27:04 AM

loooool:))) medicalstudentitis... i think almoust all of us had this... i had heart falure, colon cancer, and pulmonary fibrosis... but i managed to avoid the doctors many time (could not do it always:)
this was just sooo true:)

Posted by: Sara | Jan 9, 2006 1:57:24 PM

You've hit the nail on the head, my friend! For a long while, my mom tried to dissuade me from thinking about becoming a doctor because I kept coming down with what my pediatrician called a form of "medical student fever." Even as a small child, I would read about medical stuff and then become convinced that "this-or-that" must be wrong with me, or that I had contracted "thus-and-such" serious disease. My mother called it "being a hypochondriac" and I was usually told to stop thinking about it because it was probably nothing. Funny that now she's the one who always has to bug me to go see a doctor.

Just wait until you start diagnosing everyone you know with zebras too! And then you'll even start to cross species barriers! (I am thoroughly convinced that my dog has Marfan's-- he's hyperflexible, long and lanky, and I don't think his vision's very good, I tried to listen to his heart over Christmas break, but I didn't have much luck so I hope he's ok... guess we'll have to trust the vet. I was also convinced that he had a metabolic disorder when we first brought him home as a scrawny little puppy who had trouble eating (thanks, biochem). And over break I started to formulate the hypothesis that our other dog might be suffering from PTSD or possibly some other form of hallucinations-- she was acting really wierd at times.

Anyway, enjoy it. At least it helps us practice coming up with differential diagnoses, right?

Posted by: Kristen | Jan 9, 2006 3:37:34 PM

A zebrectomy is clearly indicated in this sitation.

Posted by: Enrico | Jan 11, 2006 9:19:17 AM

The zebras vs. horses dilemma is one that seems to me to be a central point of medicine. Learning the difference between the two hoofbeats is something that takes a lifetime to master--and many doctors don't try. Seems like some doctors assume all hoofbeats are horses and forget that if you're in Africa or at a zoo, there might be a zebra mixed in sometimes. On the other hand, if you've had a good scare from a zebra, you might assume all hoofbeats are zebras and end up ordering all sorts of unnecessary tests.

My family is full of zebras. A year before I started medical school, I saw my grandmother die of stomach/liver cancer one month after a "stomachache" that got progressively worse. Who would have picked that zebra out from those hoofbeats? Just this last summer, my uncle died of brain cancer. Hiw only symptom? A mild headache. Only looking back did we realize that the "minor collision" he was involved in was probably due to peripheral vision loss. Two months later, he was gone. The hoofbeats were zebras. I'm convinced that learning about the zebras is in some ways more important than learning about horses--the horse stuff you'll pick up over time, but if a zebra comes along, you hope you can pick it out. Another weird instance in my family--my cousin had Krabbe's disease. One of those weird biochemical diseases that you learn about in biochem but never really think about afterwards. Her only sign? not quite meeting up to her developmental milestones. Her pediatrician referred her to a peds neurologist, but it was too late. Any therapeutic treatment would have needed to have taken place months before. The zebra was found, but the hoofbeats were not able to be differentiated soon enough.

Anyways, good luck on the lifelong quest to pick out the difference between the two, even on yourself. It's never 100% easy.

Posted by: beth | Jan 17, 2006 3:22:19 PM

I came across your blog, looking for the hoof beats-zebra thing to find a good explanation of it, as I had read about it some years ago. Really enjoyed your comments on the subject. Other medical people in my family have experienced the same.

I was born a zebra (as were my sister and brothers). Out of 32 members of my family 17 are zebras, too. Then I became a zebra with wings. Now, apparently I have become a zebra with wings and a uni-horn.

Multiple Hereditary Osteochondromas
Chondrosarcoma x 7 times
40 years later, CS brain mets?

As a patient it has been difficult to get doctors to recognize my zebra type history, believe it, understand it. So, sometimes it has been frustrating before I got the tests or treatment I needed. But, by the same token, some who see the zebra foremost, associate all of my horse-ness conditions to zebra and end up with too many unnecessary tests before comfirmation of horse. It's a double-edged sword.

The saddest thing about being a zebra is that there often is not enough financial backing for appropriate research to eradicate the zebras of this world. Certainly not for Chondrosarcoma, at least.

Posted by: Elizabeth Munroz | Aug 4, 2006 9:11:18 PM

on the other hand a medical student in my class was noted to have large lymph nodes in his physical diagnosis class in his first year. in his third year he randomly was chosen by the head of ENT to be a model for an ENT exam. the chief of ENT noticed the same nodes and told him he needed a biopsy immediately.
two weeks later he was at Stanford getting his Hodgkin's treated. True story.

Posted by: bill | Aug 11, 2006 5:49:40 PM

I found this article when looking for the source of the horses vs. zebra quote. The way I first heard it was from an elderly doctor who I eventually found after exposure to Stachybotrys, a highly toxic trichothecene-producing fungi. Up to this point I had been diagnosed with everything from allergies and asthma to bipolar ADHD. He basically told me he had seen strange things happen to people exposed to this toxin, especially women. He told me the only thing I could do was avoid exposure, and that as long as I had been exposed would be the length of time it would take to clear my immune system and thus gain relief from what had become multiple chemical sensitivity. In parting, he said "When you hear the pounding of hooves it's usually just horses, but if you keep your eyes open you might see a zebra." I was a zebra; no one would believe me when I discovered the mold, and I spent a great deal of time in psychiatric hospitals because my explanation of my bizarre, psychotic symptoms seemed so preposterous.

Posted by: Rx | Jun 29, 2008 9:16:51 PM

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